Fig. 1 · Structure
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Bis-Q
ACh Agonist
Bis-Q is a selective acetylcholine (ACh) agonist, effective in voltage-clamped muscle fibers of the fish Xenomystus nigris. It exists in two isomeric forms: cis-Bis-Q, which is a non-agonist, and trans-Bis-Q, which acts as the active agonist. Photoisomerization from cis to trans form leads to the generation of agonist-induced currents, exhibiting conductance and open times similar to those of ACh. Trans-Bis-Q enhances the ratio of trans to cis forms under light, resulting in increased agonist-induced currents, particularly at elevated concentrations, making it a valuable tool for studies of muscle receptor dynamics and pharmacological responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 73711-18-9 |
| Applications | ACh Agonist |
| Formula | C20H30I2N4 |
| Molecular Weight | 580.29 |
| SMILES | C[N+](C)(CC1=CC=C(C=C1)/N=N/C2=CC=C(C=C2)C[N+](C)(C)C)C.[I-].[I-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.