Bis-sulfone NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms in native disulfide bonds. This reagent undergoes bis-alkylation to conjugate thiols from two cysteine residues, effectively rebridging interchain disulfide bonds found in proteins such as antibodies while maintaining their structural integrity. It is particularly useful in biochemical assays for studying protein interactions and modifications involving cysteine-containing thiol groups.
Bis-sulfone NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms in native disulfide bonds. This reagent undergoes bis-alkylation to conjugate thiols from two cysteine residues, effectively rebridging interchain disulfide bonds found in proteins such as antibodies while maintaining their structural integrity. It is particularly useful in biochemical assays for studying protein interactions and modifications involving cysteine-containing thiol groups.
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