Fig. 1 · Structure
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Bis-sulfone NHS ester
Biochemical Assay Reagent
Bis-sulfone NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms in native disulfide bonds. This reagent undergoes bis-alkylation to conjugate thiols from two cysteine residues, effectively rebridging interchain disulfide bonds found in proteins such as antibodies while maintaining their structural integrity. It is particularly useful in biochemical assays for studying protein interactions and modifications involving cysteine-containing thiol groups.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 899452-51-8 |
| Applications | Biochemical Assay Reagent |
| Formula | C29H27NO9S2 |
| Molecular Weight | 597.66 |
| SMILES | CC1=CC=C(S(=O)(CC(C(C2=CC=C(C(ON3C(CCC3=O)=O)=O)C=C2)=O)CS(=O)(C4=CC=C(C=C4)C)=O)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.