Bis-sulfone-PEG4-NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms in native disulfides. This reagent facilitates the bis-alkylation of two thiols derived from cysteine residues in reduced disulfide bonds, enabling the covalent rebridging of disulfide bonds, such as those in antibodies, while maintaining the protein's structural integrity. The included hydrophilic PEG spacer enhances solubility in aqueous environments, making it suitable for various biochemical assays and labeling applications.
Bis-sulfone-PEG4-NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms in native disulfides. This reagent facilitates the bis-alkylation of two thiols derived from cysteine residues in reduced disulfide bonds, enabling the covalent rebridging of disulfide bonds, such as those in antibodies, while maintaining the protein's structural integrity. The included hydrophilic PEG spacer enhances solubility in aqueous environments, making it suitable for various biochemical assays and labeling applications.
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