Fig. 1 · Structure
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Bisindolylmaleimide I hydrochloride
PKC Inhibitor
Bisindolylmaleimide I hydrochloride is a potent and selective inhibitor of Protein Kinase C (PKC), exhibiting inhibition with IC50 values of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively. Additionally, it serves as an inhibitor of Glycogen Synthase Kinase 3 (GSK-3). This compound is valuable in research investigating signal transduction pathways and cell proliferation, making it a crucial tool for studies in cancer, neurobiology, and cardiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 176504-36-2 |
| Applications | PKC Inhibitor |
| Formula | C25H25ClN4O2 |
| Molecular Weight | 448.94 |
| Synonyms | GF109203X hydrochloride; Go 6850 hydrochloride |
| SMILES | [H]Cl.O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.