Fig. 1 · Structure
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Bisindolylmaleimide V
S6K Inhibitor
Bisindolylmaleimide V is a cell-permeable inhibitor targeting S6K (p70s6k/p85s6k), a key regulator in the mTOR signaling pathway. With an IC50 of 8 µM, it effectively blocks S6K activation in response to mitogen stimuli. This compound is essential for studying the role of S6K in cellular processes and assessing pathways related to cell growth and metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 113963-68-1 |
| Applications | S6K Inhibitor |
| Formula | C21H15N3O2 |
| Molecular Weight | 341.36 |
| Synonyms | BIM V |
| SMILES | O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)N(C)C3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.