Fig. 1 · Structure
Documents & Downloads
Bisindolylmaleimide VIII acetate
PKC Inhibitor
Bisindolylmaleimide VIII acetate is a potent and selective inhibitor of protein kinase C (PKC), exhibiting an IC50 of 158 nM for rat brain PKC. It demonstrates strong inhibitory activity against various PKC isoforms, with IC50 values of 53 nM for PKC-α, 195 nM for PKC-βI, 163 nM for PKC-βII, 213 nM for PKC-γ, and 175 nM for PKC-ε. This compound is valuable for research applications related to Fas-mediated apoptosis and the modulation of T cell-mediated autoimmune responses.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 138516-31-1 |
| Applications | PKC Inhibitor |
| Formula | C26H26N4O4 |
| Molecular Weight | 458.51 |
| Synonyms | Ro 31-7549 acetate; Bis VIII acetate |
| SMILES | O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O.CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.