Fig. 1 · Structure
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Bisindolylmaleimide VIII
PKC Inhibitor
Bisindolylmaleimide VIII is a highly selective inhibitor of protein kinase C (PKC), exhibiting an IC50 of 158 nM against rat brain PKC. This compound demonstrates significant potency across various PKC isoforms, including IC50 values of 53 nM for PKC-α and 175 nM for PKC-ε. Additionally, Bisindolylmaleimide VIII promotes Fas-mediated apoptosis and serves as a valuable tool in research focused on T cell-mediated autoimmune diseases and efforts to elucidate PKC pathways in cellular signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 125313-65-7 |
| Applications | PKC Inhibitor |
| Formula | C24H22N4O2 |
| Molecular Weight | 398.46 |
| Synonyms | Ro 31-7549; Bis VIII |
| SMILES | O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.