Fig. 1 · Structure
Documents & Downloads
BIX-01294 hydrochloride hydrate
HMTase Inhibitor
BIX-01294 hydrochloride hydrate is a selective inhibitor of histone-lysine methyltransferase (HMTase), specifically targeting G9a with an IC50 of 1.7 μM. This compound effectively reduces methylation of histone H3 at lysine 9 (H3K9me), promoting autophagy and apoptosis in human glioma cells. BIX-01294 serves as a valuable tool in epigenetic research and the study of cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1808255-64-2 |
| Applications | HMTase Inhibitor |
| Formula | C28H38N6O2.3ClH.xH2O |
| Molecular Weight | 618.04 |
| SMILES | COC1=CC2=C(NC3CCN(CC3)CC4=CC=CC=C4)N=C(N5CCN(CCC5)C)N=C2C=C1OC.Cl.O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.