Fig. 1 · Structure

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BJH-86

Soluble Mitochondrial Complex 1Inhibitor

BJH-86 is a soluble mitochondrial complex I inhibitor, demonstrating an IC50 of 5 μM for the inhibition of oxygen consumption rate. This compound exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A), with an IC50 greater than 10 μM. BJH-86 effectively reduces cellular oxygen consumption and inhibits the proliferation of cancer cells. Its applications include the study of various cancer types, particularly lung cancer.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 3067849-10-6
Applications Soluble Mitochondrial Complex 1Inhibitor
Formula C23H21N3O2
Molecular Weight 371.43
SMILES
COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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