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BKI 1708

CDPK1 Inhibitor

BKI 1708 is a potent and orally bioavailable inhibitor of calcium-dependent protein kinase 1 (CDPK1), exhibiting an IC50 of 0.7 nM. This compound demonstrates significant antiprotozoal activity against Neospora, with an IC50 of 481 nM, and Toxoplasma, with an IC50 of 122 nM. BKI 1708 promotes the formation of multinucleated complexes and effectively inhibits vertical transmission of both parasites, leading to increased pup survival in mouse models. It is a valuable tool for studying CDPK1 functions and the pathology of related diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2332840-70-5
Applications	CDPK1 Inhibitor
Formula	C₂₂H₂₆N₄O₃
Molecular Weight	394.47
SMILES	O=C(C1=C(N)N(CC(C)(CO)C)N=C1C2=CC3=C(C=C(C=C3)OC4CC4)C=C2)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.