Fig. 1 · Structure
Documents & Downloads
BKM1644
Anti-cancer Drug
BKM1644 is an acyl-tyrosine bisphosphonate amide derivative targeting cancer cell proliferation. It demonstrates significant anti-cancer activity by inhibiting the growth of metastatic, castration-resistant prostate cancer (mCRPC) cells. Additionally, BKM1644 enhances the sensitivity of mCRPC cells to Docetaxel and effectively slows the progression of bone metastases in prostate cancer. This compound is primarily utilized in cancer research and therapeutic studies focused on advanced prostate cancer treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1070966-96-9 |
| Applications | Anti-cancer Drug |
| Formula | C34H37Cl2F5N2O9P2 |
| Molecular Weight | 845.51 |
| SMILES | O=C(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)N[C@@H](C(NC(P(OCC)(OCC)=O)P(OCC)(OCC)=O)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.