Fig. 1 · Structure
Documents & Downloads
BKN-1
Antineoplastic Agent
BKN-1 is an antineoplastic agent that functions as a bifunctional ligand, capable of both tracking the formation of mitochondrial G-quadruplexes through far-red emission and inducing mitochondrial dysfunction. This compound exhibits significant anti-tumor activity by promoting mtDNA loss, compromising mitochondrial integrity, decreasing ATP levels, and disrupting reactive oxygen species balance. These actions ultimately lead to apoptosis and autophagy, making BKN-1 a valuable tool for research in cancer biology and mitochondrial dynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1607831-82-2 |
| Applications | Antineoplastic Agent |
| Formula | C31H29IN2 |
| Molecular Weight | 556.48 |
| SMILES | CCN1C2=C(C=C(/C=C/C3=[N+](C)C(C=CC4=C5C=CC=C4)=C5C3(C)C)C=C2)C6=C1C=CC=C6.[I-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.