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BKT300

PRC1 Inhibitor

BKT300 is a selective inhibitor of protein regulator of cytokinesis 1 (PRC1) that effectively disrupts the dephosphorylation at T481, leading to impaired actin and microtubule formation. Its mechanism induces G2/M cell cycle arrest, mitotic catastrophe, and promotes apoptosis, ultimately inhibiting proliferation and migration of acute myeloid leukemia (AML) cells while preserving normal cell viability. In preclinical studies, BKT300 demonstrates significant inhibition of tumor growth in mouse xenograft models of AML, making it a valuable tool for research in leukemia therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2551033-16-8
Applications	PRC1 Inhibitor
Formula	C₂₂H₂₅NO₆
Molecular Weight	399.44
SMILES	O=C1NC2=C(C(O)=C1CCCCC)C=C(OC)C=C2OC3=CC=C(C=C3OC)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.