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Bleselumab
Bleselumab (ASKP 1240) is a humanized monoclonal antibody targeting CD40 with a high affinity of approximately 0.24 nM. By selectively binding to CD40, Bleselumab effectively blocks the interaction between CD40 and its ligand CD40L, a crucial pathway in immune response modulation. This inhibition is particularly relevant in preventing organ transplant rejection, making Bleselumab a significant tool in transplant immunology research.
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Biological Activity
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1453067-91-8 |
| Molecular Weight | 150000 |
| Synonyms | ASKP 1240 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.