Fig. 1 · Structure
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BLK degrader 1
BLK Inhibitor
BLK Degrader 1 is a selective degrader of B-lymphoid tyrosine kinase (BLK), a key regulator in B-cell signaling pathways. This compound exhibits significant anticancer activity across various B-lymphoid cell lines, making it a valuable tool for research into B-cell malignancies. Its targeted degradation of BLK offers potential insights into therapeutic strategies for treating cancers that involve B-lymphoid cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3049215-64-4 |
| Applications | BLK Inhibitor |
| Formula | C32H25F3N6O2 |
| Molecular Weight | 582.58 |
| SMILES | CC1=CC=C(C=C1C(NC2=CN=C(N=C2)NC3=CC=CC(N)=C3)=O)NC(C4=CC=C(C=C4)C5=CC(C(F)(F)F)=CC=C5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.