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BLU-654

KIT Inhibitor

BLU-654 is an orally active KIT inhibitor with a primary mechanism of selectively targeting wild-type KIT and PDGFRβ. This compound demonstrates substantial antineoplastic activity in preclinical models, specifically in KITV654A cell-derived xenograft mouse studies. BLU-654 is particularly valuable for research focused on addressing Imatinib-resistant gastrointestinal stromal tumors, providing insights into effective treatment options for these challenging cases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2999638-62-7
Applications	KIT Inhibitor
Formula	C₂₁H₂₈FN₇O₂
Molecular Weight	429.49
SMILES	F[C@@H](C)C1=NC(N)=CC(NC2=NC=C(C3=CN(CC(C)(O)C)N=C3)C(OC(C)C)=C2)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.