Fig. 1 · Structure
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BLU0588
PRKACA Inhibitor
BLU0588 is a potent and selective inhibitor of PRKACA (protein kinase cAMP-activated catalytic subunit alpha) with an IC50 value of 1 nM and a dissociation constant (Kd) of 4 nM. This orally active compound is primarily utilized in research focused on fibrolamellar carcinoma (FLC), where it exhibits significant biological activity against aberrant PRKACA signaling. Researchers can employ BLU0588 to investigate the therapeutic potential and mechanistic pathways involved in FLC.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2810747-78-3 |
| Applications | PRKACA Inhibitor |
| Formula | C26H25N5O |
| Molecular Weight | 423.51 |
| SMILES | O=C(C1=CN=C(C2=C3C(NC=C3)=NC=C2)C=C1)N[C@H]4[C@H](N5CCCC5)CC6=CC=CC=C64 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.