Fig. 1 · Structure
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BMS-1233
PD-L1 Inhibitor
BMS-1233 is a potent inhibitor of programmed cell death-ligand 1 (PD-L1) with an IC50 of 14.5 nM. This compound promotes cytotoxicity in HepG2 cells within a Jurkat T cell and HepG2 co-culture model, demonstrating significant antitumor activity against melanoma in in vivo mouse models. BMS-1233 is suitable for research applications focused on cancer immunotherapy and the modulation of immune checkpoint pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2447065-99-6 |
| Applications | PD-L1 Inhibitor |
| Formula | C35H33ClN2O4 |
| Molecular Weight | 581.10 |
| SMILES | N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC=C4)=C3C)=C(C=C2CN5CCCCC5C(O)=O)Cl)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.