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BMS-142

PDL1 Inhibitor

BMS-142 is a potent PDL1 inhibitor, exhibiting an IC50 of 96.7 nM and a dissociation constant (kd) of 13.2 nM. This compound demonstrates significant cytotoxic effects by reducing the survival of acute T-lymphoblastic leukemia and ovarian cancer cells. BMS-142 is suitable for research applications targeting immune evasion in cancers, particularly in studying therapies aimed at enhancing anti-tumor immunity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1675203-24-3
Applications	PDL1 Inhibitor
Formula	C₂₅H₂₆N₂O₄
Molecular Weight	418.48
SMILES	N#CC1=C(COC2=CC(OC)=C(CNCCO)C(OC)=C2)C=CC=C1C3=CC=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.