Fig. 1 · Structure
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BMS-200
PD-1/PD-L1 Interaction Inhibitor
BMS-200 is a potent inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 80 nM. This compound effectively disrupts the binding of PD-L1 to PD-1, which is critical in regulating immune responses. BMS-200 is valuable for research in cancer immunotherapy, particularly in elucidating mechanisms of immune checkpoint modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1675203-82-3 |
| Applications | PD-1/PD-L1 Interaction Inhibitor |
| Formula | C27H27F2NO6 |
| Molecular Weight | 499.50 |
| SMILES | O=C(O)C[C@H](O)CNCC1=CC(F)=C(OCC2=CC=CC(C3=CC=C(OCCO4)C4=C3)=C2C)C=C1F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.