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BMS-248360

AT1/ET(A) Antagonist

BMS-248360 is a potent dual antagonist of the angiotensin II receptor (AT1) and endothelin A receptor (ETA), exhibiting inhibition constants (Kis) of 10 nM and 1.9 nM for hAT1 and hETA, respectively. This compound demonstrates significant antihypertensive activity, making it a valuable tool for research into cardiovascular disorders and hypertension. Its dual targeting mechanism positions BMS-248360 as a promising candidate for studies aimed at understanding and treating vascular-related conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	254737-87-6
Applications	AT1/ET(A) Antagonist
Formula	C₃₆H₄₅N₅O₅S
Molecular Weight	659.84
SMILES	O=S(C1=CC=CC=C1C2=CC=C(CN3C(CCCC)=NC4(CCCC4)C3=O)C=C2CN5C(C(C)(C)CC5)=O)(NC6=C(C)C(C)=NO6)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.