Fig. 1 · Structure
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BMS-332
DGKα/ζ Inhibitor
BMS-332 is a potent dual inhibitor of diacylglycerol kinases α and ζ, exhibiting IC50 values of 5 nM and 1 nM, respectively. This compound enhances antigen-specific T cell responses and effectively reduces viral load in the liver and spleen when paired with anti-PD-1 therapies in chronic infection models. BMS-332 is a valuable tool for investigating T cell immune checkpoint strategies in immunology and related research fields.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2407892-15-1 |
| Applications | DGKα/ζ Inhibitor |
| Formula | C29H27F2N5O |
| Molecular Weight | 499.55 |
| SMILES | CN(C1=CC=C(C#N)N=C1C(N2C[C@@H](C)N(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@@H]2C)=C5)C5=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.