BMS-37 is a potent PD-1/PD-L1 immune checkpoint inhibitor, demonstrating an IC50 ranging from 18 to 200 nM against the PD-L1/PD-1 complex. This compound exhibits significant toxicity toward modified Jurkat T cells, with an EC50 between 3 and 6 µM. BMS-37 is valuable for investigating PD-L1-mediated T-cell exhaustion and serves as a PD-L1 ligand in the synthesis of PROTAC molecules for targeted protein degradation studies.
BMS-37 is a potent PD-1/PD-L1 immune checkpoint inhibitor, demonstrating an IC50 ranging from 18 to 200 nM against the PD-L1/PD-1 complex. This compound exhibits significant toxicity toward modified Jurkat T cells, with an EC50 between 3 and 6 µM. BMS-37 is valuable for investigating PD-L1-mediated T-cell exhaustion and serves as a PD-L1 ligand in the synthesis of PROTAC molecules for targeted protein degradation studies.
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