Fig. 1 · Structure
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BMS-466442
Asc-1 Inhibitor
BMS-466442 is a potent and selective inhibitor of alanine serine cysteine transporter-1 (Asc-1), demonstrating an IC50 of 11 nM. This compound effectively inhibits the uptake of [3H] D-serine in rat brain synaptosomes, with an IC50 value of 400 nM. BMS-466442 is valuable for research focused on schizophrenia and related neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1598424-76-0 |
| Applications | Asc-1 Inhibitor |
| Formula | C31H30N4O5 |
| Molecular Weight | 538.59 |
| SMILES | O=C([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C3=CC4=C(C=C(C(OC)=C4)OCC5=CC=CC=C5)N3)=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.