Fig. 1 · Structure
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BMS-505130 fumarate
Serotonin Transport Inhibitor
BMS-505130 fumarate is a potent and selective serotonin transporter inhibitor, demonstrating a binding affinity (Ki) of 0.18 nM to the serotonin transporter while presenting much lower affinities for norepinephrine and dopamine transporters (4.6 μM and 2.1 μM, respectively). This compound is primarily utilized in research focused on neurological diseases, particularly in the exploration of depression mechanisms and potential therapeutic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 859230-84-5 |
| Applications | Serotonin Transport Inhibitor |
| Formula | C19H21N3O4 |
| Molecular Weight | 355.39 |
| SMILES | O=C(O)/C=C\C(O)=O.CN(C)C[C@@H]1[C@@H](C2=CNC3=CC=C(C#N)C=C23)C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.