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BMS-737

Cytochrome P450

BMS-737 is a non-steroidal, reversible small molecule inhibitor targeting cytochrome P450, specifically exhibiting an 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. This compound is developed for the treatment of castration-resistant prostate cancer (CRPC), effectively reducing testosterone levels while having minimal impact on other steroid hormones and glucocorticoids. BMS-737 is a valuable reagent for research focusing on hormonal regulation in prostate cancer and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1356053-63-8
Applications	Cytochrome P450
Formula	C₁₆H₁₁FN₆
Molecular Weight	306.30
SMILES	FC1=CC=C(N2N=CC3=C(C4=C(N)N=CN=C4)C=CN=C32)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.