Fig. 1 · Structure
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BMS-748730
Tyrosine Kinase Inhibitor
BMS-748730 is an oral tyrosine kinase inhibitor that competes with ATP for binding at the kinase's active site. This inhibition prevents substrate phosphorylation, thereby disrupting signaling pathways involved in cell proliferation and tumor growth. BMS-748730 is particularly applicable in the investigation of chronic myeloid leukemia (CML) and other cancer types, offering valuable insights into therapeutic strategies targeting tyrosine kinases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 910297-57-3 |
| Applications | Tyrosine Kinase Inhibitor |
| Formula | C22H26ClN7O3S |
| Molecular Weight | 504.00 |
| SMILES | O=C(C1=CN=C(NC2=CC(N3CCN(CC3)CCO)=NC(C)=N2)S1)NC4=C(C)C=C(O)C=C4Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.