Fig. 1 · Structure
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BMS-764459
CRF1 Antagonist
BMS-764459 is a selective corticotropin-releasing factor 1 (CRF1) antagonist, primarily utilized in the study of neurological disorders, particularly depression and anxiety. This compound has demonstrated efficacy in mitigating the effects of stress and modulating neuroendocrine responses, making it valuable for research into psychiatric conditions. Additionally, BMS-764459 has atypical properties as a CYP1A1 inducer, suggesting potential implications in drug metabolism studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1188407-45-5 |
| Applications | CRF1 Antagonist |
| Formula | C19H21F2N5O3 |
| Molecular Weight | 405.40 |
| SMILES | N#CC(N=C1NC2=CC(C)=C(OC(F)F)N=C2C)=CN([C@@H](C3CC3)COC)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.