Fig. 1 · Structure
Documents & Downloads
BMS-820132
Glucokinase Activator
BMS-820132 is a partial glucokinase (GK) activator with an AC50 of 29 nM, demonstrating oral bioactivity. It effectively lowers glucose levels in the oral glucose tolerance test (OGTT) in normal rats, but does not produce the same effect in Zucker diabetic fatty (ZDF) rats. Due to its potent GK activation, BMS-820132 may have associated pharmacological toxicity, highlighting its potential use in research related to metabolic disorders and glucose regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1001419-18-6 |
| Applications | Glucokinase Activator |
| Formula | C26H33N6O7P |
| Molecular Weight | 572.55 |
| SMILES | O=C(NC1=NN(CP(OCC)(OCC)=O)C=C1)C2=CC(OC(C)C)=CC(OC3=NC=C(C(N4CCC4)=O)N=C3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.