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- Gijs Zonderland, .et al. The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition, Mol Cell, 2022, Sep 15;82(18):3350-3365 PMID: 36049481
- Wang C, .et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer, Nature, 2019, Oct 2 PMID: 31578521
Biological Activity
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.
Targets
| Cdc7 | Pim1 | CK2 | ||
| 3.4 nM | 42 nM | 212 nM |
| In vitro | DMSO | Insoluble | |
| Water | Warmed: 43 mg/mL (131.82 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.66 mL | 153.29 mL | 306.58 mL |
| 0.5 mM | 6.13 mL | 30.66 mL | 61.32 mL |
| 1 mM | 3.07 mL | 15.33 mL | 30.66 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.13 mL |
*The above data is based on the productmolecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13677 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1169562-71-3 |
| Formula | C14H13Cl2N3O2 |
| M. Wt | 326.18 |
| Purity | >98% |
| Synonyms | BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413 |
| SMILES | C1C[[email protected]](NC1)C2=NC(=O)C3=C(N2)C4=C(O3)C=CC(=C4)Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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