Documents & Downloads

BMS-871

Pan-Notch Inhibitor

BMS-871 is an orally active pan-Notch inhibitor, exhibiting IC50 values of 4, 1, 4, and 3 nM for Notch1, Notch2, Notch3, and Notch4, respectively. This compound effectively inhibits cell proliferation in T-acute lymphoblastic leukemia (T-ALL) and triple-negative breast cancer (TNBC) models, demonstrating considerable antitumor activity in xenograft studies. BMS-871 serves as a valuable tool for investigating the roles of Notch signaling in leukemia and breast cancer.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1584631-89-9
Applications	Pan-Notch Inhibitor
Formula	C₂₉H₂₇F₃N₄O₃
Molecular Weight	536.54
SMILES	O=C(N[C@@H]1C(N(C)C2=CC=CC=C2C(C3=CC=CC=C3)=N1)=O)[C@H](CCC(F)(F)F)[C@H](C4=CC=CC=C4)C(N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.