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BMS-952048

mGluR5 Positive Aallosteric Modulator

BMS-952048 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an EC50 of 10 nM. This compound enhances mGluR5 signaling, thereby influencing various neurological processes. It is primarily utilized in research focused on neurodegenerative diseases, anxiety, and related disorders, providing valuable insights into glutamatergic neurotransmission modulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1375751-32-8
Applications	mGluR5 Positive Aallosteric Modulator
Formula	C₂₁H₁₃F₂N₃O₂
Molecular Weight	377.34
SMILES	O=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.