BMS-952048

Catalog No.: A61897
mGluR5 Positive Aallosteric Modulator
BMS-952048 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an EC50 of 10 nM. This compound enhances mGluR5 signaling, thereby influencing various neurological processes. It is primarily utilized in research focused on neurodegenerative diseases, anxiety, and related disorders, providing valuable insights into glutamatergic neurotransmission modulation.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBMS-952048 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an EC50 of 10 nM. This compound enhances mGluR5 signaling, thereby influencing various neurological processes. It is primarily utilized in research focused on neurodegenerative diseases, anxiety, and related disorders, providing valuable insights into glutamatergic neurotransmission modulation.
Product Information
Catalog NumA61897
FormulaC21H13F2N3O2
Molecular Weight377.34
CAS Number1375751-32-8
SMILESO=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1
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