Fig. 1 · Structure
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BMS-955829
mGluR5 Modulator
BMS-955829 is a selective positive allosteric modulator of the mGluR5 receptor, with an EC50 of 2.6 nM. It exhibits no intrinsic agonist activity and demonstrates a low glutamate fold shift of 2.4. Research indicates that BMS-955829 can effectively enhance cognitive and executive function deficits in rodent models. This compound is valuable for investigating cognitive impairment disorders, including schizophrenia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1375751-08-8 |
| Applications | mGluR5 Modulator |
| Formula | C22H14F2N2O2 |
| Molecular Weight | 376.36 |
| SMILES | O=C1O[C@H](C2=CC(F)=CC=C2F)[C@@H](C3=CC(C#CC4=CC=CC=C4)=CN=C3)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.