BMS-955829 is a selective positive allosteric modulator of the mGluR5 receptor, with an EC50 of 2.6 nM. It exhibits no intrinsic agonist activity and demonstrates a low glutamate fold shift of 2.4. Research indicates that BMS-955829 can effectively enhance cognitive and executive function deficits in rodent models. This compound is valuable for investigating cognitive impairment disorders, including schizophrenia.
BMS-955829 is a selective positive allosteric modulator of the mGluR5 receptor, with an EC50 of 2.6 nM. It exhibits no intrinsic agonist activity and demonstrates a low glutamate fold shift of 2.4. Research indicates that BMS-955829 can effectively enhance cognitive and executive function deficits in rodent models. This compound is valuable for investigating cognitive impairment disorders, including schizophrenia.
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