Fig. 1 · Structure
Documents & Downloads
BMS-984923
mGluR5 SAM
BMS-984923 is a potent silent allosteric modulator (SAM) of the metabotropic glutamate receptor 5 (mGluR5), characterized by a high binding affinity (Ki = 0.6 nM). This compound effectively inhibits the interaction between PrPC and mGluR5, thereby preventing pathological signaling associated with amyloid-beta oligomers while preserving normal glutamate signaling. BMS-984923 is suitable for research applications related to neurodegenerative diseases and offers favorable pharmacokinetic properties, including enhanced oral bioavailability and the ability to cross the blood-brain barrier.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1375752-78-5 |
| Applications | mGluR5 SAM |
| Formula | C22H15ClN2O2 |
| Molecular Weight | 374.82 |
| SMILES | O=C1O[C@H](C2=CC=CC=C2Cl)[C@@H](C3=CC(C#CC4=CC=CC=C4)=CN=C3)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.