Fig. 1 · Structure
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BMS-986122
µ-Opioid Receptor Positive Allosteric Modulator
BMS-986122 is a selective positive allosteric modulator of the mu-opioid receptor (µ-OR) that enhances the activity of orthosteric agonists. This compound effectively increases β-arrestin recruitment, inhibits adenylyl cyclase, and activates G protein signaling pathways. BMS-986122 demonstrates the ability to potentiate DAMGO-mediated [35S]GTPγS binding in mouse brain membranes, making it a valuable tool for research in pain management and opioid pharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 313669-88-4 |
| Applications | µ-Opioid Receptor Positive Allosteric Modulator |
| Formula | C16H15BrClNO3S2 |
| Molecular Weight | 448.78 |
| SMILES | O=S(N1C(C2=CC=C(OC)C(Br)=C2)SCC1)(C3=CC=C(Cl)C=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.