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BMS-986144

NS3/4A Protease Inhibitor

BMS-986144 is a potent, third-generation NS3/4A protease inhibitor targeting hepatitis C virus (HCV) replication. It demonstrates strong antiviral activity with EC50 values of 2.3 nM for GT-1a, 0.7 nM for GT-1b, 1.0 nM for GT-2a, and 12 nM for GT-3a, alongside effective outcomes against resistant strains with EC50s of 8.0 nM and 5.8 nM for 1a R155X and 1b D168V, respectively. This compound is valuable for research applications aimed at understanding HCV infection and developing antiviral therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1606150-08-6
Applications	NS3/4A Protease Inhibitor
Formula	C₄₀H₄₈D₃F₄N₅O₉S
Molecular Weight	856.94
SMILES	O=C([C@H]1N2C[C@@H](C1)OC3=NC=CC4=C3C=C(C(OC([2H])([2H])[2H])=C4)F)N[C@@]5(C[C@H]5/C=C\CC[C@H](C[C@H]([C@@H](C2=O)NC(OC(C)(C(F)(F)F)C)=O)CC)C)C(NS(C6(CC6)C)(=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.