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Biological Activity
BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease.
| In vitro | DMSO | 27 mg/mL (63.46 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.5 mL | 117.52 mL | 235.04 mL |
| 0.5 mM | 4.7 mL | 23.5 mL | 47.01 mL |
| 1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18726 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1609392-27-9 |
| Formula | C20H19D3N8O3 |
| M. Wt | 425.46 |
| Purity | >98% |
| Synonyms | BMS-986165; BMS 986165; BMS986165; |
| SMILES | O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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