Fig. 1 · Structure
Documents & Downloads
BMS-986169
GluN2B Inhibitor
BMS-986169 is a selective inhibitor of the glutamate N-methyl-D-aspartate 2B receptor (GluN2B), targeting its allosteric regulatory site with a high binding affinity (Ki = 4.03-6.3 nM). It effectively inhibits GluN2B receptor function in Xenopus oocytes, exhibiting an IC50 value of 24.1 nM. Additionally, BMS-986169 has been shown to inhibit the hERG channel with an IC50 of 28.4 μM. This compound is valuable for research into treatment-resistant depression and related neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1801151-08-5 |
| Applications | GluN2B Inhibitor |
| Formula | C23H27FN2O2 |
| Molecular Weight | 382.47 |
| SMILES | O=C1N(CC[C@H]1N2C[C@H]([C@@H](CC2)C3=CC=C(C=C3)O)F)CC4=CC=C(C=C4)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.