Fig. 1 · Structure
Documents & Downloads
BMS-986202
Tyk2 Inhibitor
BMS-986202 is a potent and selective inhibitor of Tyk2, binding to the Tyk2 JH2 domain with an IC50 of 0.19 nM and a Ki of 0.02 nM. This compound exhibits remarkable selectivity over other kinases, particularly within the Jak family, while showing weak inhibitory activity against CYP2C19 with an IC50 of 14 μM. BMS-986202 is valuable for research applications targeting IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1771691-34-9 |
| Applications | Tyk2 Inhibitor |
| Formula | C22H18D3FN6O3 |
| Molecular Weight | 439.46 |
| SMILES | O=C(NC1=NC=C(C(NC2=CC=CC(C3=NC=C(C=N3)F)=C2OC)=C1)C(NC([2H])([2H])[2H])=O)C4CC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.