Fig. 1 · Structure
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BMS-986238
PD-L1 Inhibitor
BMS-986238 is an orally active macrocyclic peptide that functions as a PD-L1 inhibitor. This compound exhibits significant anti-tumor activity by blocking the PD-1/PD-L1 interaction, enhancing immune responses against cancer cells. BMS-986238 is utilized in research applications focusing on solid tumors and lymphomas, providing insights into immune checkpoint modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2919596-13-5 |
| Applications | PD-L1 Inhibitor |
| Formula | C143H224N26O40S |
| Molecular Weight | 2979.52 |
| SMILES | C(C=1C=2C(N(CC(O)=O)C1)=CC=CC2)[C@H]3C(=O)N(C)[C@@H](CCCC)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(NCC(N[C@@H](CC4=CN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)N=N4)C(O)=O)=O)=O)CSCC(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N6[C@](C(=O)N[C@@H](CN)C(=O)N[C@@H](CC(C)C)C(=O)N7[C@](C(=O)N[C@@H](CC=8C=9C(NC8)=CC=CC9)C(=O)N[C@@H](CCN)C(=O)N3)(C[C@@H](O)C7)[H])(CCC6)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.