Fig. 1 · Structure
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BMS-986308
ROMK Inhibitor
BMS-986308 is an orally active and selective inhibitor of the renal outer medullary potassium (ROMK) channel. This compound demonstrates specificity for ROMK while exhibiting minimal interaction with the hERG channel. BMS-986308 is primarily utilized in research focused on heart failure, providing valuable insights into renal potassium handling and potential therapeutic targets in cardiovascular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2254333-97-4 |
| Applications | ROMK Inhibitor |
| Formula | C24H25N7O2 |
| Molecular Weight | 443.50 |
| SMILES | CC1=C(COC2=O)C2=CC=C1[C@@H]3CN(C[C@@H](N3)C)CC4=NN(C5=CC(C)=C(C=N5)C#N)N=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.