Fig. 1 · Structure
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BNS
PHD2 inhibitor
BNS is a potent and selective inhibitor of prolyl-hydroxylase 2 (PHD2), known for its ability to penetrate cell membranes effectively. This compound modulates hypoxia-inducible factors (HIFs) by inhibiting PHD2 activity, which is crucial for cellular responses to oxygen levels. BNS is applicable in research associated with cancer biology, metabolism, and the study of cellular hypoxic responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1417440-37-9 |
| Applications | PHD2 inhibitor |
| Formula | C18H16N2O6S2 |
| Molecular Weight | 420.46 |
| SMILES | O=C(CC1=CS/C(N1O)=N\C(CS(=O)(CC2=CC=C3C=CC=CC3=C2)=O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.