Fig. 1 · Structure
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BOLD-100 free base
Anticancer Agent
BOLD-100 free base is a ruthenium-based anticancer agent that primarily targets endoplasmic reticulum (ER) homeostasis. By inhibiting stress-induced upregulation of GRP78, it induces ER stress and activates the unfolded protein response (UPR). This compound also influences the intricate relationships between ER-stress responses, lysosome dynamics, and the execution of autophagy, making it a valuable tool for cancer research focused on cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 783324-98-1 |
| Applications | Anticancer Agent |
| Formula | C14H12Cl4N4Ru |
| Molecular Weight | 479.15 |
| Synonyms | NKP-1339 free base; IT-139 free base; KP-1339 free base |
| SMILES | [Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.