Fig. 1 · Structure
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Boldine
RANKL/RANK Inhibitor
Boldine, a RANKL/RANK inhibitor, is an isoquinoline alkaloid derived from the root of Litsea cubeba. This compound exhibits significant antioxidant, anti-inflammatory, and antitumor properties, effectively inhibiting osteoclast formation. Boldine induces apoptosis in human bladder cancer cells through modulation of key signaling pathways involving ERK, AKT, and GSK-3β. Additionally, it has therapeutic potential in bone diseases by down-regulating the OPG/RANKL/RANK signaling axis, making it valuable for research in rheumatoid arthritis and related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 476-70-0 |
| Applications | RANKL/RANK Inhibitor |
| Formula | C19H21NO4 |
| Molecular Weight | 327.37 |
| SMILES | OC1=C(OC)C2=C3C(CCN(C)[C@@]3([H])CC4=CC(O)=C(OC)C=C24)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.