Fig. 1 · Structure
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BPH-1358
FPPS/UPPS Inhibitor
BPH-1358, a selective inhibitor of farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS), demonstrates potent inhibitory activity with IC50 values of 1.8 μM and 110 nM, respectively. This compound exhibits significant antimicrobial effects against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) around 250 ng/mL. BPH-1358 is a valuable tool for studying bacterial lipid synthesis and for potential applications in antimicrobial drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 5352-53-4 |
| Applications | FPPS/UPPS Inhibitor |
| Formula | C32H30Cl2N6O2 |
| Molecular Weight | 601.53 |
| Synonyms | NSC50460 |
| SMILES | O=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.