Fig. 1 · Structure
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BPK-21
ERCC3 Blocker
BPK-21 is an active acrylamide that selectively inhibits the function of ERCC3, a critical helicase involved in DNA repair and T cell activation. By targeting C342 in the ERCC3 protein, BPK-21 effectively suppresses T cell activation, making it a valuable tool for research in immunology and cancer therapy. This compound aids in understanding the role of DNA repair mechanisms in T cell responses and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2305052-77-9 |
| Applications | ERCC3 Blocker |
| Formula | C23H16Cl2F3NO2 |
| Molecular Weight | 466.28 |
| SMILES | C=CC(N(CC1=CC=CC(Cl)=C1Cl)C2=CC=C(OC3=CC=CC=C3)C(C(F)(F)F)=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.