Fig. 1 · Structure
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BPK-25
NuRD Complex Proteins degrader
BPK-25 is a potent degrader of nucleosome remodeling and deacetylation (NuRD) complex proteins, operating through a post-translational mechanism that involves covalent modification of target proteins. This compound effectively inhibits TMEM173 activation induced by the cyclic dinucleotide ligand cGAMP. BPK-25 is valuable for research applications focusing on the modulation of epigenetic regulation and signal transduction pathways linked to immune responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2305052-86-0 |
| Applications | NuRD Complex Proteins degrader |
| Formula | C21H17ClN4O2 |
| Molecular Weight | 392.84 |
| SMILES | O=C(N(CC1=NC(Cl)=CC=C1)C2=CN=C(C(NC3=CC=CC=C3)=O)C=C2)C=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.