Fig. 1 · Structure
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BPN-15477
SMC
BPN-15477 is a potent splicing modulator compound (SMC) that targets the ELP1 (Elongator complex protein 1) exon 20 to restore accurate splicing. By correcting the splicing of the ELP1 transcript, BPN-15477 significantly enhances the levels of functional protein across various tissues, including the brain. This compound is valuable for research in frontotemporal dementia, enabling investigations into the molecular mechanisms underlying this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1971086-99-3 |
| Applications | SMC |
| Formula | C12H10ClN5 |
| Molecular Weight | 259.69 |
| SMILES | ClC1=NC2=C(C=CN2)C(NCC3=CC=NC=C3)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.