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Biological Activity
BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
| In vitro | DMSO | 71 mg/mL (174.96 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | 71 mg/mL (174.96 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.64 mL | 123.21 mL | 246.43 mL |
| 0.5 mM | 4.93 mL | 24.64 mL | 49.29 mL |
| 1 mM | 2.46 mL | 12.32 mL | 24.64 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.93 mL |
*The above data is based on the productmolecular weight 405.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18663 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1606974-33-7 |
| Formula | C21H15ClF3NO2 |
| M. Wt | 405.8 |
| Purity | >98% |
| Synonyms | BPN 14770, BPN-14770 |
| SMILES | O=C(O)CC1=CC=C(CC2=CC(C3=CC=CC(Cl)=C3)=NC(C(F)(F)F)=C2)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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