Fig. 1 · Structure
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BpV(phen) trihydrate
PTP/PTEN Inhibitor
BpV(phen) trihydrate is a potent inhibitor of protein tyrosine phosphatases (PTPs) and PTEN, demonstrating IC50 values of 38 nM for PTEN, 343 nM for PTP-β, and 920 nM for PTP-1B. This reagent exhibits significant anti-parasitic activity against Leishmania in vitro and effectively stimulates the secretion of various chemokines and pro-inflammatory cytokines, activating a Th1-type immune response characterized by IL-12 and IFNγ production. Additionally, BpV(phen) trihydrate promotes apoptosis in certain cell types and possesses anti-angiogenic and anti-tumor properties, making it valuable for research in cancer and immunology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 171202-16-7 |
| Applications | PTP/PTEN Inhibitor |
| Formula | C12H14KN2O8V |
| Molecular Weight | 404.29 |
| Synonyms | Bisperoxovanadium(phen) trihydrate |
| SMILES | O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.O.O.O.[K+] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.